• As we all known hypoxia is a hallmark

  2019-12-27

  

  As we all known, hypoxia is a hallmark of tumour microenvironment, which is a key regulator of tumour growth and metastasis [4]. Hypoxia meditates a series of cellular responses including angiogenesis by activating transcriptional factor hypoxia inducible factor (HIF), which is consist of an obligat

• bcr-abl tyrosine kinase inhibitors This study evaluated the

  2019-12-27

  

  This study evaluated the role of SERT in classical fear conditioning using a SERT knockout rat model. We found a clear disruption of cue-conditioned fear in SERT−/− rats, as measured with the fear-potentiated startle. This disruption was due to a deficit in fear acquisition and was accompanied by de

• In particular EphB has been one of the most studied

  2019-12-27

  

  In particular, EphB4 has been one of the most studied receptor of the Eph family: inhibition of EphB4 expression using interfering-RNA or antisense oligonucleotides inhibited proliferation, survival and invasion of PC3 prostate cancer amanitin australia in vitro and in vivo. Inhibition of EphB4 sig

• br Conclusion br Introduction Biological wastewater

  2019-12-27

  

  Conclusion Introduction Biological wastewater treatment is targeted towards the removal of phosphorous, nitrogen and organic substances by the metabolic activity of a diverse activated sludge microbial community. More precisely, it is based on the versatile catalytic activity of the microbial

• A robust meta analysis of randomized clinical trials found t

  2019-12-27

  

  A robust meta-analysis of 22 randomized clinical trials found that application of ischemic preconditioning strategies reduce ventricular arrhythmias [3]. Additionally, it was demonstrated that remote ischemic perconditioning (perRIC) induces immediate cardioprotection during ongoing ischemia by atte

• Urolithin A br Conclusion br Introduction br CRL E ligases

  2019-12-27

  

  Conclusion Introduction CRL4 E3 ligases in tumorigenesis Small molecule-based PROTACs PROTAC: Major biological impacts Acknowledgements The authors sincerely apologize to all those colleagues whose important work was not cited in this paper owing to space limitations. They thank th

• In this study we implicate SCFFBXO E ligase as

  2019-12-27

  

  In this study, we implicate SCFFBXO3 E3 ligase as a critical modulator of inflammation in atherosclerosis and demonstrate the efficacy of a small molecule FBXO3 inhibitor in suppressing inflammatory responses important in atherosclerosis. Specifically, individuals carrying a hypofunctioning genetic

• DDR expression is upregulated in the glomeruli and tubules o

  2019-12-26

  

  DDR1 expression is upregulated in the glomeruli and tubules of injured kidneys [7], [8], [19]; however, what role this receptor plays in kidney resident ODQ is unclear. A plausible hypothesis is that DDR1 might contribute to kidney injury by directly exerting a pro-fibrotic action. In favor to this

• More importantly Santagata et al have suggested a

  2019-12-26

  

  More importantly, Santagata et al. have suggested a new breast cancer subtyping method according to ER, androgen receptor (AR), and VDR with a higher prognostic value than the ordinarily used method based on ER, progesterone receptor (PR) and Her2 (Santagata et al., 2014). This implies that such com

• MSCs are self renewing multipotent progenitor cells with mul

  2019-12-26

  

  MSCs are self-renewing, multipotent progenitor cells, with multilineage potential to differentiate into adipocytes, osteocytes, and chondrocytes. In addition, MSCs can migrate to sites of inflammation, supporting hematopoiesis and homeostatic maintenance. Given their unique therapeutic properties, M

• br Molecular modeling study Molecular modeling study was

  2019-12-26

  

  Molecular modeling study Molecular modeling study was essentially needed to understand and interpret the DHFR inhibitory pattern of this new class of compounds. Computational docking is an algorithm designed to estimate two main terms. The first is to determine the suitable position and the orien

• br Type II NAD P H Dehydrogenases in Fungi

  2019-12-26

  

  Type II NAD(P)H Dehydrogenases in Fungi Fermentative YeastSaccharomyces cerevisiaeBecause S. cerevisiae is a facultative ABT yeast capable of meeting its energy requirements with ATP generated by fermentation, only relatively few mitochondrial proteins are essential for cell viability. The mitoch

• br Type II NAD P H Dehydrogenases in Fungi

  2019-12-26

  

  Type II NAD(P)H Dehydrogenases in Fungi Fermentative YeastSaccharomyces cerevisiaeBecause S. cerevisiae is a facultative Fmoc-Gln(Trt)-OPfp yeast capable of meeting its energy requirements with ATP generated by fermentation, only relatively few mitochondrial proteins are essential for cell viabil

• In Hevea brasiliensis both the

  2019-12-26

  

  In Hevea brasiliensis, both the soluble PPase and the membrane-bound V-PPase are present in the latex; the soluble PPase is in the C-serum (cytosol) of the latex [6] and the V-PPase is on the tonoplast of the lutoid, a special vacuole in the laticifers of rubber trees [7]. The V-PPase on the lutoid

• Iodoacetyl-LC-Biotin Autophagy alterations are frequently re

  2019-12-26

  

  Autophagy alterations are frequently reported as one of the pathological mechanisms contributing to neurodegenerative diseases, due to incomplete removal of protein Iodoacetyl-LC-Biotin in the brain [30,41]. It was over a decade ago when mutations in PARK8 encoding for the LRRK2 protein were descri

15409 records 936/1028 page Previous Next First page 上5页 936937938939940 下5页 Last page